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Distribution of responses (size of induration) to purified protein derivative associated with 4 isolated nontuberculous mycobacterial species: complex (MAC), (HAEM), (SCROF), and (SIM) Horizontal lines indicate median values.

Figure 1
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Distribution of responses (size of induration) to purified protein derivative associated with 4 isolated nontuberculous mycobacterial species: complex (MAC), (HAEM), (SCROF), and (SIM) Horizontal lines indicate median values.

Discussion . This study shows that, in ~50% of immunocompetent children with nontuberculous mycobacterial cervical lymphadenitis, the indurative reaction to M. tuberculosis PPD measures ⩽15 mm by the ball-pen method, and in ~25%, it measures <10 mm. Although large indurations have been found among adults infected with various nontuberculous mycobacterial species [ 4 ], the incidence of large indurations found here is greater than that reported elsewhere in series of children with cervical lymphadenitis. Wolinsky [ 5 ] reviewed results of 105 American children with presumed nontuberculous mycobacterial lymphadenitis (83 culture-proven cases), of whom 91 underwent a PPD skin test; only 7 children (8%) showed indurations of >15 mm, whereas 57 (63%) had indurations of ⩾10 mm. In another study from Greece, among 43 of 47 pediatric inpatients with presumed nontuberculous mycobacterial lymphadenitis (40 culture-proven cases) who underwent a tuberculin test, the median induration was 7 mm (range, 0–15 mm), and most patients (70%) had indurations of <10 mm [ 6 ].

Discussion

Differences between our results and those from different parts of the world [ 5 , 6 ] may indicate the existence of different nontuberculous mycobacterial species and subspecies. This diversity may result from regional environmental factors that affect mycobacterial cell wall structure and, consequently, immunogenicity.

In fact, in contrast to previous reports among children with nontuberculous mycobacterial lymphadenitis [ 5–7 ], we had a high isolation rate of M. haemophilum. This might be the result of a high prevalence of this species in our geographic area, but it may also be attributable to our laboratory routine of use of broth with an iron supplement incubated at 30°C for processing aspirated specimens [ 3 ]. Correa and Starke [ 8 ] claimed that the size of reactions to M. tuberculosis PPD in infections caused by M. avium-intracellulare complex is usually 0–10 mm and rarely exceeds 18 mm, whereas infections caused by other species, especially Mycobacterium marinum and Mycobacterium fortuitum , are frequently associated with reactions of 10–20 mm. Because of scant data, it is impossible to estimate the range of indurative responses to M. tuberculosis PPD in children infected with M. haemophilum in other parts of the world. Nevertheless, our series shows that this species can occasionally be very immunogenic.

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Nick Sullivan -

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Author Nick Sullivan worked for six years at Apple on many of its most important cryptography efforts before recently joining CloudFlare, where he is a systems engineer. He has a degree in mathematics from the University of Waterloo and a Masters in computer science with a concentration in cryptography from the University of Calgary. This post was originally written for the CloudFlare blog and has been lightly edited to appear on Ars.

Readers are reminded that elliptic curve cryptography is a set of algorithms for encrypting and decrypting data and exchanging cryptographic keys. Dual_EC_DRBG, the cryptographic standard suspected of containing a backdoor engineered by the National Security Agency , is a function that uses elliptic curve mathematics to generate a series of random-looking numbers from a seed. This primer comes two months after internationally recognized cryptographers called on peers around the world to adopt ECC to avert a possible "cryptopocalypse ."

Elliptic curve cryptography (ECC) is one of the most powerful but least understood types of cryptography in wide use today. An increasing number of websites make extensive use of ECC to secure everything from customers' HTTPS connections to how they pass data between data centers. Fundamentally, it's important for end users to understand the technology behind any security system in order to trust it. To that end, we looked around to find a good, relatively easy-to-understand primer on ECC in order to share with our users. Finding none, we decided to write one ourselves. That is what follows.

Be warned: this is a complicated subject, and it's not possible to boil it down to a pithy blog post. In other words, settle in for a bit of an epic because there's a lot to cover. If you just want the gist, here's the TL;DR version: ECC is the next generation of public key cryptography, and based on currently understood mathematics, it provides a significantly more secure foundation than first-generation public key cryptography systems like RSA. If you're worried about ensuring the highest level of security while maintaining performance, ECC makes sense to adopt. If you're interested in the details, read on.

The history of cryptography can be split into two eras: the classical era and the modern era. The turning point between the two occurred in 1977, when both the RSA algorithm and the Diffie-Hellman key exchange algorithm were introduced. These new algorithms were revolutionary because they represented the first viable cryptographic schemes where security was based on the theory of numbers; it was the first to enable secure communication between two parties without a shared secret. Cryptography went from being about securely transporting secret codebooks around the world to being able to have provably secure communication between any two parties without worrying about someone listening in on the key exchange.

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gives client his payment terms, he notes that he will first send a low-res preview of the finished work, for the client to approve and accept. Once the client has accepted the work, Alsan requires that they send payment before he releases the original file. It’s a clever way to conduct the transaction, especially when dealing with a new client. “This method is like the optimal way to secure a payment,” says Aslan. “It creates trust, because every time you get paid, you send them a proof about the work done.”

Pay yourself the equivalent of a salary, so you have a year-round income

For those whose earnings ebbs and flows throughout the year, it can be impossible to count on a regular income. So once you have built up a steady roster of existing clients, DENIM Denim trousers Maison Espin Cheap Sale Pay With Paypal KG7j4JbyZ
. A predictable pay structure allows you to work and live with the predictability and structure of a salaried employee.

JUCO Photography co-founder Julia Gardo and her co-founder Cody Cloud —whose clients include Target, Lexus and Apple—use this system at their two-person agency. Incoming checks are distributed among the various JUCO business expenses—including agent fees, taxes and overhead—and the rest is put in a compensation account. Gardo and Cloud then pay themselves the same amount every month, whether they did a $10,000 or $50,000 job that month. “We can’t have less than $40,000 in the account,” says Gardo. “That is so we know we are able to pay ourselves out.”

Sweat the small, nitpicky stuff related to money

Contracts, invoices, tax forms, expenses reports, budgets – no creative truly likes pouring through these kinds of documents. But think of them as the glue that holds your business together. As such, you’ve got to both continuously review and properly store them (and no, shoving them into the back of a drawer doesn’t count as “storing” them.) I like to use Friday afternoon when I’m tuckered out from my creative projects to firm up all of my loose financial ends – sending out invoices, tracking expenses, and combing through my contracts to make sure all is well and fair.

Of all the meetings you take, the recurring one focused on keeping your finances tidy is the arguably the most important. At least once a month sit down and review your finances so you’re aware of what’s coming in and going out. And, if you’re like me and you need an assist in the numbers / legal departments, you can always hire an accountant or lawyer to do it. That way you both protect your financial and operations flank, while freeing up your time for your creative pursuits.

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Matt McCue is the Editor-in-Chief of99U.He lives in New York City, but he is willing to travel long distances for a good meal. Find him @ mattmccuewriter or email him atmccue@adobe.com.

Statistical analysis

Demographic and behavioral characteristics of women infected with M. genitalium. The 50 women (7.0%) who were positive for M. genitalium were significantly younger, less likely to have more than a high school education or an income, and somewhat less likely to have been married at any point (P=.06) than were the 669 women without M. genitalium infection ( table 1 ). These 2 groups were similar with respect to race. Women positive for M. genitalium were less likely to use any contraception (P=.02) and somewhat more likely to have been pregnant during the year before the sample was obtained (P=.08) or to have had a spontaneous miscarriage at any point (P=.13)

Demographic and behavioral characteristics of women infected with
Table 1
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Demographic, gynecologic, and behavioral characteristics of 719 women with and without Mycoplasma genitalium infection who attended the Harborview Sexually Transmitted Disease Clinic, 1984–1986

Table 1
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Download slide

Demographic, gynecologic, and behavioral characteristics of 719 women with and without Mycoplasma genitalium infection who attended the Harborview Sexually Transmitted Disease Clinic, 1984–1986

Women infected with M. genitalium were significantly younger at sexual debut, had engaged in sexual intercourse more recently, more often reported having ⩾2 new sex partners in the past 30 days or having douched at least 2 times each month, and were more likely to smoke, but less often reported ever receiving cunnilingus. Associations between M. genitalium and demographic, gynecologic, and sexual behavior characteristics were similar in magnitude and statistical significance after women with N. gonorrhoeae and C. trachomatis infections were excluded, with the exception of time since last sexual intercourse, which was no longer statistically significant (data not shown)

Clinical and microbiologic findings associated with detection of M. genitalium. Women with M. genitalium infection had significantly higher vaginal and cervical PMNL counts, more often had cervical mucopus, and were somewhat more likely to have easily induced cervical bleeding than were women without such infection (P=.06) ( table 2 ). MPC was present in 48.0% of women with and 28.6% of women without M. genitalium (P=.004). Women with M. genitalium complained significantly more often of abdominal pain, vaginal discharge described as abnormal or as brown or bloody, or nausea, diarrhea, and vomiting in the previous 30 days and were more often in the proliferative phase of the menstrual cycle (days 6–14). There was no association with uterine, adnexal, abdominal, or cervical motion tenderness (data not shown)

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